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A blood test is the only reliable way to determine whether B12 deficiency is causing fatigue

The 2.8 mg dose remains fixed while frequency decreases

They can also support overall wellbeing where appropriate

If you are using oral capsules, none of the above applies you only need the capsules themselves

The Guidelines are intended to give an understanding of a clinical problem, and outline one or more preferred approaches to the investigation and management of the problem

Researchers should consult primary literature (PubMed, Google Scholar) before designing experiments and confirm dose-ranges, vehicle compatibility, and analytical methods against the published methodology