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(8) Treatment of opioid withdrawal in the ED is based on patient desire for treatment, last opioid use (and type of opioid used), COWS score, and the ability to arrange reliable follow-up within 3 days of presentation to the ED (ideally, next day)

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This can lead to reduced effectiveness or increased side effects of Suboxone

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In additional embodiments, the concentration of active pharmaceutical ingredient between about 10 and about 50 mM

Dose-matched transitions therefore introduce the heart-rate, liver-fat, and fat-release effects of glucagon at once