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J Biol Chem 282:68236832 Tao R, Coleman MC, Pennington JD, Ozden O, Park S-H, Jiang H, Kim H-S, Flynn CR, Hill S, McDonald WH (2010) Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress

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This inhibition of endogenous GNE resulted in 70% reduction in GNE expression and 80% 2 reduction in total cellular sialylation 15

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