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This pathway safely degrades homocysteinea potentially toxic byproduct of metabolisminto cysteine through two sequential enzymatic steps involving cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE)

Once water-soluble, these neutralized toxins can be safely and efficiently excreted from the body through bile and urine

Dumbrava EI, Balaji K, Raghav K, Javle M, Blum-Murphy M, Sajan B, Kopetz S , Broaddus R, Routbort M, Pant S, Tsimberidou A, Subbiah V, Hong DS, Ahnert JR, Shaw K, Piha-Paul S, Meric-Bernstam F