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SCHEME 1 The final compounds -L-H-Glu(L-Glu-OH)OH 2 (( S , S ) 4-amino-4-carboxybutanoyl) glutamic acid) as chlorhydrate salt were obtained in 90% yield by removing N -BOC and tert butyl esters protecting groups in acidic conditions using HCl 4N aqueous solution in dioxane (Scheme 2)

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Several studies point to the importance of BDNF in pathways of adult neurogenesis [163], suggesting it might contribute to the effect of nutrients on among others the adult neurogenic process

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1996 Mitochondrial permeability transition is a central coordinating event of apoptosis J