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Although anti-IGF-IR mAbs and IGF-IR inhibitors have potent anti-cancer effects in preclinical models, clinical trials of these agents are largely disappointing in unselected cancer patients

Collectively, these analyses suggest that the mesolimbic reward system may be more potently engaged with GLP-1MK-801 than semaglutide treatment

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10.1186/1476-511X-9-42 236

While several small molecular inhibitors targeting specifically KRAS G12C have been developed and tested clinically, alternative approaches are still necessary due to expected drug resistance