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When NAD+ levels are adequate, SIRT1 activity increases, promoting DNA repair, reducing inflammation, and enhancing stress resistance

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Most B12 injections deliver a high dose typically 1,000 mcg of cyanocobalamin or hydroxocobalamin directly into muscle tissue

Those with naturally high NNMT activity might respond more dramatically to inhibition, while those with lower baseline activity might see more modest effects

Women specific considerations Women generally require lower doses relative to body weight compared to men

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