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Rather than manipulating hormones, suppressing appetite, or artificially stimulating the nervous system, it works at the level of basic cellular energy production and storage

Silent information regulator 1 (Sirt1), an anti-inflammatory and anti-oxidative protein (316), increases the production of NO by activating endothelial NOS (eNOS) in endothelial cells in response to shear stress (317)

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Model building was conducted for ANOVA (using ANCOVA) and linear mixed models to see if certain covariates were needed (i.e., age, sex, FFQ)

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