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Interestingly, GFR remained increased even 14 days after cessation of rhIGF-1 therapy compared to placebo-treated controls, suggesting that rhIGF-1 resulted in renal hypertrophy, since the hemodynamic effects should have worn off within 14 days of cessation

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532,557559 It has been argued that the ancestral role of MarR family proteins was to maintain physiological homeostasis by sensing and derepressing the expression of genes encoding efflux pumps for both toxic metabolites as well as unnatural xenobiotics

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In this case, it can be unhealthy and even toxic