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Secondary endpoints included the proportion of participants achieving 5% and 10% body weight reduction, absolute weight change in kg, change in waist circumference, lipid parameters including total cholesterol, HDL, LDL, VLDL, triglycerides, and glycaemic variables such as HbA1c, fasting glucose, insulin, HOMA-IR, and -cell function

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Breaking this cycle requires interventions at multiple points: suppressing the aberrant immune response, protecting oligodendrocytes from ongoing damage, promoting remyelination of denuded axons, and reducing the oxidative stress and neuroinflammation that perpetuate the process

[DOI] [PubMed] [Google Scholar] 767

From its origins as a textile dye to its emergence as a clinical powerhouse, Methylene Blue has captivated researchers with its myriad applications