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Moreover, overexpression of cGAS in RA-FLSs enhanced both the proliferation of these cells and the expression of pro-inflammatory factors ( Sting1 +/ mice, which have a reduced expression of phosphorylated TBK1, showed a decreased severity of arthritis and improved histological changes compared to control mice ( Figure 2 )

Thompson, A., Abbott, J., Deans, R., & Kingston, A

This is expected pharmacology, not an unexpected side effect

Metformin, commonly prescribed for diabetes, and proton pump inhibitors used for acid reflux can both reduce B12 absorption over time

Regulatory fibroblast-like synoviocytes cell membrane coated nanoparticles: A novel targeted therapy for rheumatoid arthritis