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These findings highlighted the importance of host factors such as granuloma structure and immune environment in determining the efficacy of JAK blockers [14]

Fibrosis and smooth muscle proliferation are prominent in both adenomyotic and deep endometriotic lesions, forming dense collagen fibers that reinforce adhesions and structural alteration

The release of 5-HT remains unchanged in IBS patients, but the decreased expression of SERT may impair the uptake of 5-HT, which increases the availability of 5-HT in the mucosa, enhancing reflex activity and triggering IBS-D

(PubMed) Charoensiriwatana W, Srijantr P, Teeyapant P, Wongvilairattana J

It can support a fresher and more balanced appearance when used in a simple routine

Hawkes WC, Alkan Z, Wong K