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On the positive side, melatonins accessibility, affordability, and potential benefits position it as a promising intervention that requires further testing

Researchers without access to regular bloodwork and medical oversight

Individuals seeking steady hormone elevation rather than pulsatile patterns

It is recommended that future studies investigate the potential side effects of vitamin D, particularly those associated with high-dose or long-term supplementation, such as hypercalcaemia or drug interactions

GPER and nonalcoholic fatty liver disease (NAFLD) NAFLD, a metabolic disorder characterized by hepatic fat accumulation [163], has emerged as one of the most prevalent liver disorders worldwide, and its incidence has increased sharply in recent years [164]

Interaction With Medications NAD+ supplements may interact with certain medications