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Further analysis of aged mice testes after FOXO4-DRI treatment revealed a reduction in interstitial SA--gal activity, along with decreased levels of senescence-associated proteins p53, p21, and p16

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Examination of the promoter of Cdkn1a, the gene encoding p21 Cip1 , showed a canonical FOXO target sequence to be flanked by two p53 binding sites (Fig

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