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Under normal conditions, TNF- signaling facilitates the recruitment of RIPK1 kinase to the plasma membrane, forming membrane-associated complex , which includes RIPK1, TRADD, TNF receptor-associated factor (TRAF), and cellular inhibitors of apoptosis proteins (cIAP1/2) (Holler et al., 2000)

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Pyroptosis Pyroptosis, a type ofprogrammed cell death, relies on inflammasome activation, characterized by cellular swelling, membrane disruption, and the secretion of pro-inflammatory cytokines [230]

(2021) Effectiveness of N-acetylcysteine in treating clinical symptoms of substance abuse and dependence: a meta-analysis of randomized controlled trials

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