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Conditional GPX4 knockout mice exemplify the risks of single-pathway targeting: while GPX4 deletion in PT cells protects against early AKI by eliminating damaged cells, long-term deletion activates the cGASSTING pathwaylikely via release of fragmented mitochondrial DNAleading to sustained type I interferon signaling and progressive interstitial fibrosis

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In this experimental setting, atrophy was evident in soleus muscle, but was absent in extensor digitorum longus (EDL) muscle, following 91 days of long-term exposure to real microgravity in space

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This myth has several underlying causes: Confusion between lyophilized powders and solutions