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Methylation Capacity Second, NNMT inhibition affects cellular methylation capacity: SAM is required for hundreds of methyltransferase reactions throughout the cell, and NNMT's consumption of SAM can deplete this critical resource, while the SAH produced by NNMT is a potent product inhibitor of many methyltransferases

Malabsorption disorders represent the most common cause in the general population, particularly among older adults

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Fortified foods (breakfast cereals, plant-based milk alternatives) provide options for vegetarians and vegans