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More effective preventing cartilage loss than regenerating severely damaged cartilage

This is primarily relevant for HSC70 (Roperto, 2022), although BAG3 has also been shown to associate with HSPA1A, increasing its activity (Xia et al., 2025) or together with HSP70, as shown by Ruggiero and colleagues reporting the first known inhibitor targeting both BAG3HSP70 (Ruggiero et al., 2025)

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This is the result that will matter

The authors did not receive support from any organization for the submitted work

Some patients experience significant progress, and their traits may become less noticeable or no longer meet full diagnostic criteria