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J Clin Invest 129:40014008 IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, International Agency for Research on Cancer, World Health Organization (2007) Smokeless tobacco and some tobacco-specific N-nitrosamines, vol 89

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45, 46, 53 Tobacco smoke contains many substances that can activate DCs either directly or indirectly by triggering the release of danger signals and pro-inflammatory mediators from resident lung cells, which could be sensed by a wide range of DC-expressed receptors (Table 1)

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