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NAD+ is crucial as a coenzyme in reactions that generate ATP (energy) in cells, and it also serves as a substrate for enzymes involved in DNA repair and gene regulation

[DOI] [PubMed] [Google Scholar] 237.Vorhees C.V., Williams M.T

In a 2001 study published in Endocrinology , Heffernan and colleagues reported that chronic AOD-9604 administration reduced body weight gain, decreased adipose tissue mass, and increased fat oxidation in obese mice without altering IGF-1 levels or glucose metabolism effects that were abolished in beta3 adrenergic receptor (3-AR) knockout mice, implicating 3-AR signaling as the mechanism of action [1]

Rosenfeld, R

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