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Due to the Brattleboro homozygous vasopressin-deficient rat's reduced sensitivity to several ulcerogenic stimuli compared to the rat with normal vasopressin secretion, endogenous vasopressin has been shown to operate as an aggressive factor towards the gastroduodenal mucosa [21]

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It is possible that nicotine exposure, by increasing the release of dopamine, causes psychosis to develop. A proven link has already been found between cannabis use and psychosis in genetically-vulnerable people