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47,131,133,139149 These inhibitors may target upstream signaling events, such as potassium efflux, 81 mitochondrial dysfunction, 150 or lysosomal destabilization, 151,152 all critical for NLRP3 activation

For these reasons, GPx is especially significant in protecting of mitochondria against H 2 O 2 ,that are constantly generated during cell respiration [40, 41]