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This enzyme represents a key regulatory point, subject to inhibition by malonyl-CoA (the first committed intermediate in fatty acid synthesis)

& Quinn, J

these components are well documented to produce oxidative damage, proteolytic cleavage of extracellular and cellular proteins, and direct cytotoxicity in other tissue contexts [56]

In addition, second-line treatments such as GnRH agonists effectively reduce pain but are compromised by significant menopausal side effects and challenges with long-term tolerability, which has prompted the development of novel oral GnRH antagonists like elagolix, linzagolix, and relugolix that offer dose-dependent estrogen suppression and rapid reversibility

Hsu CN, Hou CY, Chan J, et al

Collectively, this dual exhaustion effect significantly boosts OH production and improves therapeutic effect