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Initially, these phagocytes adopt a pro-inflammatory, microbicidal program characterized by elevated production of reactive oxygen species (ROS), nitric oxide (NO), proteolytic enzymes, and pro-inflammatory cytokines like IL-1, IL-6, and TNF-, enabling efficient pathogen clearance [39]

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One study found copper-peptide complexes decreased inflammatory cytokines (IL-6 and TNF-alpha) produced by dermal fibroblasts

The most cited clinical trial is the open-label MASLD pilot by Honda et al., in which 300 mg/day oral glutathione for 4 months reduced ALT and hepatic steatosis in 29 patients, but without histological or survival data and with no control arm ( The impact of glutathione supplementation on this cohort presents a complex picture that requires careful interpretation