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The premise underlying the leaky gut hypothesis is that physiologic stressors such as anxiety, intensive exercise, or dietary components such as emulsifiers increase intestinal mucosal paracellular permeability, enhancing entry of pathogenic bacteria and bacterial toxins into the systemic circulation, provoking systemic inflammation and triggering numerous diseases

In yet other embodiments, the otic formulations or compositions include a penetration enhancer excipient

Pentadecapeptide BPC 157, in clinical trials as a therapy for inflammatory bowel disease (PL14736), is effective in the healing of colocutaneous fistula in rats

Despite these sources, vitamin D deficiency is common

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Therapeutic Advances in Drug Safety, 13 , 20420986221125010