The lack of a suggestion of trend and the lack of a point estimate suggesting an increase in GSH status or reduction in oxidative stress suggest type 2 error is not responsible for our findings
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It is generally well-tolerated, with the following side effects [9][18]: GI symptoms (most common): Nausea, vomiting, diarrhea, and abdominal discomfort, particularly at doses above 1,200 mg/day Sulfurous taste/smell: NAC has a distinct sulfur odor and taste that some find unpleasant Headache: Occasionally reported Anaphylactoid reactions (IV use only): Infusion-related reactions including flushing, itching, bronchospasm, and hypotension occur in approximately 10-20% of patients receiving IV NAC for acetaminophen overdose [18] Upper limit: There is no established UL for NAC
"Effects of oral glutathione supplementation on systemic oxidative stress biomarkers in human volunteers." J Altern Complement Med
Handle in accordance with standard laboratory safety procedures
Adair JC, Knoefel JE, Morgan N
