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(172) studied 37 adult patients with active epilepsy and found that fasting during Ramadan might have a positive impact on seizure control, with this effect persisting for up to 1 month after fasting, without affecting quality of life scores

Subsequently, 64 subjects with high levels of Pb in blood were divided, randomly, into two groups

Chronic stress, prolonged stimulant use, or repeated exposure to cholinergic agents can downregulate nicotinic and muscarinic acetylcholine receptors

These alterations in levels have likely taken years to manifest resulting in well-established functional deficits

Korphaisarn K, Chou CK, Xia WY, Clarke CN, Katkhuda R, Davis JS, Raghav KP, Liao HW, Wu JY, Menter DG, Maru DM, Hung MC, Kopetz S

A 2026 review in Frontiers in Aging confirmed this range, citing multiple rodent studies