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It would be of interest to investigate whether the miRNA contents of ApoE, aside from being cell specific, are also isoform-dependent
Additionally, it has the potential to provide a new and effective early diagnostic intervention, thereby improving the chances of successful treatment
Some JAK inhibitors are effective against one isoform, like decernotinib (under phase III) inhibits only JAK3, AC-410 (under phase I) inhibits only JAK2, and filgotinib (under phase III) [80], and INCB-047986 (under Phase I) inhibits only JAK1, are under clinical investigations
Recently discontinuous iodixanol gradients have been used to purify these cells [13-19] 2
