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Telomeres are protective caps on the ends of chromosomes, and their shortening is a major factor in cellular aging

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Frontiers in Neurology , 11, 662.

Lancet 351 : 13931396 Heron-Milhavet L, LeRoith D (2002) Insulin-like growth factor I induces MDM2-dependent degradation of p53 via the p38 MAPK pathway in response to DNA damage