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Other studies have found that the level of GPX4 in brain tissue decreases significantly 24 h after cerebral hemorrhage, while increasing the level of GPX4 significantly reduces neuronal dysfunction, brain edema, blood-brain barrier damage, oxidative stress and inflammatory damage after cerebral hemorrhage, and the application of the ferroptosis inhibitor Fer-1 also significantly reduces the extent of secondary brain injury after cerebral hemorrhage 74

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HIF-1 was found to ameliorate mitochondrial dysfunction and limit mitochondria-dependent apoptosis in DN tubular cells via Heme Oxygenase 1(HO-1)

Chan EC, Peshavariya HM, Liu G-S, Jiang F, Lim S-Y, Dusting GJ

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