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In general, disordered domains are unsuitable targets for potent peptide binding because of the lack of well-defined binding surfaces, conformational flexibility, and associated entropic penalties 60,61
These segments bear the most mechanical stress during daily activities, making them particularly vulnerable to injury and degeneration
If standardized peptide formulations can be verified and administered within controlled protocols, these agents may represent a future adjunct to evidence-based perioperative care, particularly in populations undergoing TJA where wound healing, metabolic health, and inflammatory regulation strongly influence outcomes
Application of mesenchymal stem cells in inflammatory and fibrotic diseases
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