ApoB48 is required for the synthesis and secretion of triglyceride-rich chylomicrons, which play a critical role in the intestinal absorption of dietary fats and fat-soluble vitamins
Major limitations, before their large-scale clinical application, are still represented by: (i) appropriate quality control for CNS biocompatibility and safety, including their complete, efficient and fast clearance/reabsorption, (ii) establishment of the ideal mechanism of NP-mediated drug delivery into the brain, and (iii) a careful consideration of the multiple factors that may affect NP efficacy into the brain microenvironment, such as the ideal material, size and shape, surface modification
P743: the pivotal role of glutaminolysis in myelodysplastic syndrome (mds): a novel strategy for the targeted therapy of mds
and (7) it is likely that a successful approach to treating AD will require several different multiple target directed ligands (MTDLs)
10.1186/s12951-022-01654-9 J
R., Brzechffa, P