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With the invention of standard-sized lighter-flints in the early 1900s, mankind realised that portable firelighting was now possible, and on a scale much larger than just a box of matches

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Retrieved 21 March 2011

113, 114 The involvement of extracellular ATP and uric acid and the activation of the Nalp3inflammasome complex in the abrogation of inhalational tolerance and induction of aberrant Th2-driven inflammation by cigarette smoke represents an interesting working hypothesis for further investigation