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2 Lack of clear explanation regarding the treatment protocols or the types of cells used in the therapy

In the nucleus, following heterodimer complex formation with transcription factors, like small Maf proteins (G/F/K) and c-Jun, Nrf2 complexes bind to the antioxidant response element (ARE), a regulatory enhancer region within gene promoters that upregulate antioxidant and anti-inflammatory defense processes (Cuadrado et al., 2019

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Estrogen decline following menopause is associated with increased incidence and severity of OA

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