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Later, Galen (129216 CE) advanced the humoral imbalance theory, proposing that attacks resulted from an accumulation of melancholic bile or overheated blood ( Senkyunolides, a class of phthalide compounds isolated from Ligusticum chuanxiong and related plants, demonstrate multifaceted pharmacological activities including anti-inflammatory, analgesic, and microcirculation-enhancing effects

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Most of these peptides are so-called "research chemicals" that are not approved by the U.S