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Preclinical studies document significant brain concentrations after systemic (including oral) administration, with behavioral improvements in hippocampal-dependent tasks confirming functionally relevant CNS penetration (PMID: 23055539)

958 For example, high throughput selection and counter-selection strategies have led to the development of metal ion-specific DNAzymes with unprecedented metal specificity that continue to teach us how nucleic acids distinguish among various transition metal ions, while also creating reagents for applications as biosensing tools

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Last reviewed: April 2026

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