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In particular, folate is needed for closure of the neural tube early in pregnancy, and periconceptional supplementation with folic acid (that is, supplementation beginning one month before and continuing two months after conception) has been shown to dramatically reduce the incidence of neural tube defects (NTDs) (reviewed in 29 and 30)

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[69] [70] [71] Unlike the first film, A Dame to Kill For was a commercial failure, grossing US$39 million against its US$65 million production budget, [72] and received mixed reviews from film critics

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Supplementing with vitamin B12 lowers homocysteine levels and may improve mood, particularly in response to stress

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