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ECCO guidelines on therapeutics in ulcerative colitis: medical treatment

Zang et al

Notably, a recent study found that LAT1 was a pH-dependent but not pH-independent transporter, whose maximal transporter activity is at neutral pH but much lower at acidic pH (Cosco et al., SLC7A5 ) imports BCAAs and several essential amino acids (e.g., phenylalanine, leucine, isoleucine, tryptophan, histidine, and tyrosine) with high affinity in exchange for the efflux of intracellular histidine, tyrosine, and glutamine (Nicklin et al., 2009

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What are the potential risks and side effects I should be aware of

Recent studies have revealed that precancerous lesions of HGSOC are primarily located in the fallopian tube epithelium and are driven by TP53 mutations (7,26,54)