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l-Proline is a competitor also in a putP knockout mutant background Because l-proline likely competes with 5OP on its binding site in an unknown sensor and because PutP is required for l-proline internalization, the ability of l-proline to act as a competitor in a putP knockout mutant would allow to elucidate if 5OP sensing is internal or external

10.1093/eurheartj/ehr007 43 CarrollC

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Metformin, a diabetes drug, alters the gut microbiome and increases SCFAs and bile acids that activate GLP-1, which has led to exploration of metformin in AD and PD trials for its possible MGBA benefits [278, 279]