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doi: 10.3389/fmed.2023.1124275 Received 14 December 2022 Accepted 27 February 2023 Published 22 March 2023 Volume 10 - 2023 Edited by Ana Sandoval-Rodriguez, University of Guadalajara, Mexico Reviewed by Angelo Armandi, University of Turin, Italy

Conclusion: Your Path to Successful Concussion Rehabilitation Concussion represents a serious trauma that profoundly affects blood-brain barrier integrity, making proper concussion therapy essential for complete recovery

Indeed, it was recently reported that treatment of cells with H 2 O 2 , which can lower GSH levels, leads to increased expression of NRF2 target genes in a KEAP1-independent mechanism 69

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The peptide prevents both excessive proteolysis that impairs healing and insufficient matrix turnover that creates rigid, dysfunctional scar tissue

Practical considerations for researchers Beyond the clinical data, practical factors influence which compound works better in real-world research settings