Thats not the type of rigorous research needed to establish standard medical care
In addition, people who have undergone gastrointestinal surgery may have a reduced ability to naturally absorb this vitamin from food
(What the Evidence Shows) Short answer: not on their own
Conclusion To answer the original question directly: high B12 levels themselves don't typically cause symptoms
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Therefore, there must be common endogenous mechanisms beyond and outside of the mentioned systems: dopamine, serotonin, glutamate, GABA, adrenergic/noradrenergic system, acetylcholine, and NO-systems