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Retatrutide, like other drugs in the GLP-1 class, crosses the blood-brain barrier and influences dopamine signalling in the nucleus accumbens, the brains primary reward centre

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49 Secondly, its safety and efficacy remain unclear in patients with a history of pancreatitis as it has not been studied in this group

The once-daily dosing frequency combined with the long plasma half-life of semaglutide (~ 1 week) cause multiple previous doses to contribute to the exposure at steady state