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Hoeffer CA, Dey A, Sachan N, Wong H, Patterson RJ, Shelton JM, Richardson JA, Klann E, Rothermel BA (2007) The Down Syndrome Critical Region Protein RCAN1 Regulates Long-Term Potentiation and Memory via Inhibition of Phosphatase Signaling

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Nearly 50% of the cases are attributed to chromosomal aberrations, nevertheless, there is further evidence linking substantially higher rates of miscarriage to factors involving ethnic origin, the mother's psychological state, extremely high or low BMI pre-pregnancy, stress, smoking, use of non-steroidal anti-inflammatory drugs, and alcohol consumption

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