They usually occur in the initial phase of starting the treatment or during dose escalation, but improve over time
Many people on semaglutide experience fatigue, especially as they consume fewer calories
It can also be taken as an oral supplement or as a prescription nasal spray or injection/infusion for people who have vitamin B12 deficiency
The origins of these symptoms are unclear, but they may be related to the stomach inflammation underlying some cases of vitamin B 12 deficiency and to the progressive destruction of the lining of the stomach (21)
The most substantial body of human-adjacent research involves early-phase trials for inflammatory bowel disease conducted by the Croatian pharmaceutical company PLIVA in the 2000s which have never been published in indexed, peer-reviewed journals
Again, evidence is primarily animal-based, not FDA approved