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The practical implications of this difference extend to manufacturing, patent protection, dosing flexibility, and potentially even clinical outcomes

J Neurosci 29:1392913944 Peterson PE, Smith TJ (1999) The structure of bovine glutamate dehydrogenase provides insights into the mechanism of allostery

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For instance, two siblings both harboring the same mitochondrial mutation causing Lebers hereditary optic neuropathy had markedly different clinical courses: the brother exhibited typical progressive optic neuropathy whereas the sister suffered from a relapsingremitting MS-like illness (Joshi and Kermode, 2019)