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Stuendl A, Kunadt M, Kruse N, Bartels C, Moebius W, Danzer KM, et al

Neuroscience and Biobehavioral Reviews via PubMed (PMID 29733881), 2018 The development of small molecule angiotensin IV analogs to treat Alzheimer's and Parkinson's diseases (review note the authors were affiliated with M3 Biotechnology, a company commercializing dihexa)

The activity of several protein kinases, and particularly of protein kinase C (PKC) sub-family members can be modulated in human neuronal cells supplemented with tocopherols and tocotrienols (Galli et al., 2017)

When administered, it rapidly restores vitamin B12 levels, particularly benefiting those with disorders of red blood cell production and nervous system anomalies due to deficiency

Due to this feature, they are also chemically sensitive

Animal physiology differs significantly from humans, limiting direct translation