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AOC, chloroalanine and -FBP were reported to inhibit SLC1A5-mediated glutamine uptake and cell viability in melanoma cell in vitro, just like benzyl serine, the effective doses were apparently too high for clinical application(at the range of mM) [50]

Br J Dermatol (1965) 77:4254

PMID 28678785

The study authors found that intravenous injection of 42mg to 1260mg of TB4 was safe in healthy adults, with no dose limiting toxicities or serious adverse events reported [26]

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