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This is when people often consider increasing protocol intensity if results are modest

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In contrast, CAR T cells in the day 28 BM of STR had significantly higher expression of PD-1 compared to the pre-infusion product, suggesting that CAR T cells of STR may have acquired an exhausted or over-activated phenotype post-infusion (Fig

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Ion imbalance, particularly excessive accumulation of sodium ions (Na + ) coupled with potassium (K + ) deficiency [7], further compromises membrane integrity and disrupts osmotic homeostasis during exposure to saline-alkali stress condition