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Low Volume of Distribution 5 A drug with a low V d (e.g., less than 15 L) demonstrates a propensity to remain primarily within the vascular compartment (plasma)

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Fed-batch culture of the penta-mutant ZJ12345 was performed where the GshF expression level was enhanced, and both the GSH production (19.10 mM) and the yield based on added l-cysteine (0.76 mmol/mmol) were significantly increased

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Sterile Product Development: Formulation, Process, Quality and Regulatory Considerations

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