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Further, 5-FU is also known to affect iron homeostasis, where 5-FU administration significantly raises Fe 2+ levels in vivo [30]

[PubMed: 16757551] 60

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NAPQI is a strong oxidising agent and has the potential to cause liver and kidney damage by reacting with cellular and mitochondrial proteins [21]

Animal models showed that these characteristics can induce ASD-associated behavior, suggesting an intimate relationship between the microbiota, gut, immune system and the brain in ASD

Typical ingredients include retinoids, vitamin C derivatives, hydroquinone equivalents, antimicrobials and antioxidants